3-(4-phenoxyphenyl)-1-(3-piperidyl)pyrazolo[3,4-d]pyrimidin-4-amine

Fa'amatalaga Puupuu:

CAS: 1022150-12-4

MF: C22H22N6O

MW: 386.45

EINECS: 200-001-8

Vaega o oloa: Ibrutinib;Intermediates

Auina imeli ia matou

Fa'amatalaga Oloa

Faailoga o oloa

Synonyms

2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)

(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

3-(4-phenoxyphenyl)-1-(3R)-3-piperidinyl-1H-Pyrazolo[3,4-d]pyrimidin-4-amine

3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine

Ibrutinib intermeidate N-1

(R)-3-(4-FLUOROPHENYL)BUTANOIC ACID

ibrutinib N-1

(R)-3-(p-fluorophenyl)butanoic acid

Ibrutinib (PCI-32765) Intermediates

Btk inhibitor 1 (R enantioMer)

Meatotino tau vailaau

Mea fa'apuna: 626.3±55.0 °C(Va'ai)

Malosi: 1.39±0.1 g/cm3(Va'ai)

vevela vevela.: Taofi i se nofoaga pogisa, Inert atemosifia,2-8°C

pka: 9.00±0.10(Va'ai)

Faailoaina o lamatiaga

1 Fa'avasegaina o mea po'o fa'afefiloi

leai ni fa'amatalaga e maua

2 GHS faʻailoga elemene, e aofia ai faʻamatalaga puipuia

Pictogram(s)	leai ni fa'amatalaga e maua
Upu faailo	leai ni fa'amatalaga e maua
Fa'amatalaga o lamatiaga	leai ni fa'amatalaga e maua
Fa'amatalaga puipuia
Puipuiga	leai ni fa'amatalaga e maua
Tali	leai ni fa'amatalaga e maua
Teuina	leai ni fa'amatalaga e maua
Lafoai	leai ni fa'amatalaga e maua

3 O isi lamatiaga e le i'u i fa'avasegaga

leai ni fa'amatalaga e maua

Fa'amatalaga Fa'amatalaga

PFuga fa'aletino: pa'epa'e i samasama malo

Fa'ailoa (E le HPLC):E fetaui

Purity(e le HPLC): 97%

Vai (KF):≤0.5%

Svevela vevela: vevela potu

Catunuu na tupuga mai ai: Saina

O Tatou Fa'amanuiaga

1 O a matou oloa o loʻo gaosia i totonu o le fale faʻapitoa e ISO9001: 2015 Faʻamaonia.

2O lau suʻesuʻega o le a taliina i totonu ole 24 itula.E leai se fa'agata o le sami.

3E mafai ona e fesili i se tafaoga vitio i la matou falegaosimea.

4E mafai ona mamanuina le lelei o oloa e pei o ou manaʻoga.

O tatou lelei

1: Na iloa e le matou fale gaosi oloa le tele o gaosiga faʻapisinisi talu mai le tausaga 2012, o le aofaʻi o faʻatauga faʻaletausaga na oʻo atu i le 20tons.
2 Sa avea ma tagata fa'atauva'a fa'apitoa mo pateni kamupani vaila'au a le Ibrutinib.
3 E sili le lelei o oloa: Su'ega: 97.0% -103.0%
Vailaau mama (GC area): ﹦ 99.0%
So'o se fa'aleaga le fa'ailoaina ﹤ ﹦ 0.08%
Ole mama a'ia'i (vaega HPLC): ﹥ ﹦ 99.5%
4 E faia i le auala o le Resolution Chemical.
5 Ua fa'amaonia uma metotia su'ega.
6 Tasi a'oa'oga fa'apitoa mo le faia.