Welcom i Sichuan Hengkang Science and Technology Development Co., Ltd.

(S)-1-Boc-3-hydroxypiperidine

Fa'amatalaga Puupuu:

image4

CAS: 143900-44-1

MF: C10H19NO3

MW: 201.26


Fa'amatalaga Oloa

Faailoga o oloa

Vaega o oloa

ChiralReagents;Piperidines;Heterocycles;Itu vavalo & Vailaau Matagofie;Pharmaceuticals;Anticancer

Synonyms

(S)-1-Boc-3-Hydroxypiperidine

(S)-1-N-BOC-3-HYDROXY-PIPERIDINE

(S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(S)-3-HYDROXY-1-(TERT-BUTOXYCARBONYL)PIPERIDINE

(S)-1-BOC-3-PIPERIDINOL

(S)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPIPERIDINE HYDROCHLORIDE

(S)-N-BOC-3-PIPERIDINE HYDROXY

(S)-TERT BUTYL-3-HYDROXYPIPERIDINE-1-CARBOXYLATE

(S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine

S-1-Boc-3-hydroxypiperidine

(3S)-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

(S)-3,5-DifluoroMandelic acid

(S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate

(S)-tert-Butyl-3-hydroxypiperidine-1-carboxylate tert- butyl

(3S)-3-hydroxy piperidine-1-carboxylate tert-butyl

(S)-3-hydroxypiperidine-1-carboxylate

(3S)-3-Hydroxypiperidine, N-BOC puipuia

(S)-N-tert-Butoxycarbonyl-3-hydroxypiperidine

Meatotino tau vailaau

Liu liusuavai: 34-40 °C

Mea fa'apuna: 292.3±33.0 °C(Va'ai)

Malosi: 1.107±0.06 g/cm3(Va'ai)

Fp: 110 °C

vevela le teuina: Taofi i le nofoaga pogisa, Faamaufaailoga i le mago, Potu vevela

solubility: Solu i le methanol.

Pka: 14.74±0.20(Va'ai)

Fomu: Pa'u po'o le Pa'u tioata

Lanu: Pa'epa'e e 'ena'e

gaioiga fa'apitoa: [α]22/D +10.0°, c = 1 ile chloroform

InChIKey: UIJXHKXIOCDSEB-QMMMGPOBSA-N

Faailoaina o lamatiaga

1 Fa'avasegaina o mea po'o fa'afefiloi

Fa'aitagofie le pa'u, Vaega 2

Mata ita, Vaega 2

O'ona fa'apitoa fa'atatau ole totoga - fa'aalia tasi, Vaega 3

2 GHS faʻailoga elemene, e aofia ai faʻamatalaga puipuia

Pictogram(s)  image5
Upu faailo Lapataiga
Fa'amatalaga o lamatiaga H315 E fa'aoso ai le pa'u

H319 Mafua ai le tiga mata'utia

H335 E ono mafua ai le manava manava

Fa'amatalaga puipuia
Puipuiga P264 Fufulu ... mae'a lelei pe a uma ona tagofia.

P280 Fai totigilima puipui/ofu puipui/puipui mata/puipui foliga/puipuiga fa'alogo/...

P261 Aloese mai le manavaina o le pefu/susa/kasa/sau/ausa/suusa.

P271 Fa'aaoga na'o fafo po'o se nofoaga e fa'aalili lelei.

Tali P302+P352 AFAI I LE PA'U: Fufulu ile tele o vai/...

P321 Togafitiga fa'apitoa (va'ai ... i luga o lenei igoa).

P332+P317 Afai e tupu le ita o le pa'u: Saili fesoasoani faafoma'i.

P362+P364 Aveese lavalava ua pisia ma fufulu a'o le'i toe fa'aoga.

P305+P351+P338 AFAI I MATA: Fufulu ma le faaeteete i le vai mo ni nai minute.Aveese tioata fa'afeso'ota'i, pe a iai ma faigofie ona fai.Fa'aauau le fufulu.

P304+P340 AFAI ILOA: Aveese le tagata i le ea fou ma fa'amalie lelei mo le manava.

P319 Maua se fesoasoani faafoma'i pe a e lagona le le lelei.

Teuina P403+P233 Teu i se nofoaga e savili lelei.Taofi mau le pusa.

P405 Faleoloa loka.

Lafoai P501 Lafoa'i mea o lo'o i totonu/koneteina i se nofoaga talafeagai mo togafitiga ma lafoai e tusa ai ma tulafono ma tulafono fa'atatau, ma uiga o oloa ile taimi e lafoa'i ai.

3 O isi lamatiaga e le i'u i fa'avasegaga

leai ni fa'amatalaga e maua

Fa'amatalaga o oloa

Fa'aaliga/lanu Pa'epa'e e pa'epa'e pa'epa'e
E mafai ona fa'aputu pe a uma ona teuina mo se taimi umi
Fa'asinomaga (IR) E fetaui
Su'ega(HPLC w/w) 97.0%-103.0%
Fa'amama vaila'au (vaega GC) ﹦ 99.0%
Mama le mama (GC w/w) 3-Hydroxypiperidine﹦ 0.1%
3-Hydroxypyridine﹦ 0.20% Le iloa
1-Boc-3-piperidone﹦ 0.10% Le iloa
1-Boc-4-hydroxypiperidine﹦ 0.10% Le iloa
1.96RRRT﹦ 0.2% Le iloa
So'o se fa'aleaga lē fa'ailoaina﹦ 0.08% 0.01%
Chiral mama (vaega HPLC) ﹦ 99.5%
Methanol(GC) ﹦ 50ppm
Etanol(GC) ﹦ 50ppm
DCM(GC) ﹦ 500ppm
Vai (KF vol w/w) ﹦ 0.5%

O tatou lelei

1: Na iloa e le matou fale gaosi oloa le tele o gaosiga faʻapisinisi talu mai le tausaga 2012, o le aofaʻi o faʻatauga faʻaletausaga na oʻo atu i le 20tons.
2 Sa avea ma tagata fa'atauva'a fa'apitoa mo pateni kamupani vaila'au a le Ibrutinib.
3 E sili le lelei o oloa: Su'ega: 97.0% -103.0%
Vailaau mama (GC area): ﹦ 99.0%
So'o se fa'aleaga le fa'ailoaina ﹤ ﹦ 0.08%
Ole mama a'ia'i (vaega HPLC): ﹥ ﹦ 99.5%
4 E faia i le auala o le Resolution Chemical.
5 Ua fa'amaonia uma metotia su'ega.
6 Tasi a'oa'oga fa'apitoa mo le faia.


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